2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Neurotensin Receptor

Neurotensin Receptor

Neurotensin Receptor

Related Products

PDF 0.31 MB

The neuropeptide neurotensin (NT) exerts central actionsthat include hypothermia, analgesia, and a number of effects that involve the modulation of nigrostriatal and mesocortico-limbic dopaminergic pathways. The two neurotensin receptor subtypes known to date, NTR1 and NTR2, belong to the family of G-protein-coupled receptors with seven putative transmembrane domains (TM). The NTR1 has high affinity for neurotensin, whereas the NTR2 has lower affinity for the peptide and is selectively recognized by levocabastine, an anti-histamine H1 receptor antagonist. These receptors have widespread, though not identical, central and peripheral distributions and exhibit distinct ontogenic profiles.

It is notably reported that NTR1 activation results in significant antinociception but also causes marked hypotension and hypothermia. In sharp contrast, NTR2 has emerged as an important pain target because NTR2-selective analogues exhibit potent analgesic activity in both acute and chronic pain conditions in dose-dependent analgesic effects without inducing drop in blood pressure or body temperature.

Neurotensin Receptor Isoform Specific Products:

Neurotensin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1255
    Kinetensin
    		Agonist 99.89%
    Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.
    Kinetensin
  • HY-P1256C
    JMV 449 acetate
    		Agonist 99.84%
    JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC50 of 0.15 nM for inhibition of 125I-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse.
    JMV 449 acetate
  • HY-P0253
    Xenopsin
    		Agonist 99.98%
    Xenopsin, a neurotensin-like octapeptide from Xenopus laevis skin. Xenopsin is an inhibitor of Tetragastrin stimulated gastric acid secretion.
    Xenopsin
  • HY-161903
    Progranulin modulator-3
    		Inducer 99.95%
    Progranulin modulator-3 (compd C40) is a brain-penetrant and orally active progranulin (PGRN) inducer. Progranulin modulator-3 can be used for neurological research.
    Progranulin modulator-3
  • HY-RS09638
    NTSR1 Human Pre-designed siRNA Set A
    		Inhibitor

    NTSR1 Human Pre-designed siRNA Set A contains three designed siRNAs for NTSR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    NTSR1 Human Pre-designed siRNA Set A
    NTSR1 Human Pre-designed siRNA Set A
  • HY-148650A
    (R)-Sortilin antagonist 1
    		Antagonist
    (R)-Sortilin antagonist 1 is a sortilin antagonist that blocks the sortilin mediated apoptosis pathway by interfering with the binding of sortilin to its ligand pro-neurotrophin. (R)-Sortilin antagonist 1 can be used in the study of hearing loss.
    (R)-Sortilin antagonist 1
  • HY-107761
    JMV 390-1
    JMV 390-1 (Compound 6a) is a potent multipeptidase inhibitor. JMV 390-1 behaves as a full inhibitor of the major neurotensin (NT)/neuromedin N (NN) degrading enzymes in vitro with IC50 values from 30 to 60 nM. JMV 390-1 increases endogenous recovery of NT and NN from slices of mice hypothalamus depolarized with potassium.
    JMV 390-1
  • HY-P1257A
    Xenin-8 TFA
    Xenin-8 TFA, a C-terminal octapeptide, is a biologically active fragment of Xenin. Xenin is a 25-amino acid peptide of the neurotensin/xenopsin family. Xenin-8 TFA stimulates basal insulin secretion and potentiates the insulin response to glucose in a dose-dependent manner (EC50=0.16 nM).
    Xenin-8 TFA
  • HY-153688
    SORT-PGRN interaction inhibitor 3
    		Inhibitor
    SORT-PGRN interaction inhibitor 3 (Compound 13) is a SORT-PGRN interaction inhibitor (IC50: 0.17 μM). SORT-PGRN interaction inhibitor 3 can be used for research of neurodegenerative diseases.
    SORT-PGRN interaction inhibitor 3
  • HY-RS09639
    Ntsr1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ntsr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ntsr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ntsr1 Mouse Pre-designed siRNA Set A
    Ntsr1 Mouse Pre-designed siRNA Set A
  • HY-P0253A
    Xenopsin TFA
    		Agonist
    Xenopsin TFA, a neurotensin-like octapeptide from Xenopus laevis skin. Xenopsin TFA is an inhibitor of Tetragastrin stimulated gastric acid secretion.
    Xenopsin TFA
  • HY-P4223
    Acetyl neurotensin (8-13)
    Acetyl neurotensin (8-13) is the shortest analog of neurotensin with full binding and pharmacological activities.
    Acetyl neurotensin (8-13)
  • HY-14277
    Levocabastine
    		Antagonist
    Levocabastine (R 50547) is a potent and selective histamine H1-receptor antagonist. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a Ki of 17 nM for mNTR2. Levocabastine can act as a VLA-4 antagonist, interferes with conjunctival eosinophil infiltration in allergic conjunctivitis (AC).
    Levocabastine
  • HY-153687
    SORT-PGRN interaction inhibitor 2
    		Inhibitor
    SORT-PGRN interaction inhibitor 2 is a SORT-PGRN inhibitor that can decreases SORT1 protein expression and increases extracellular PGRN secretion in mammalian cell lines. SORT-PGRN interaction inhibitor 2 can be used for neurological disease research.
    SORT-PGRN interaction inhibitor 2
  • HY-139668
    VGD071
    		Inhibitor
    VGD071, a sortilin-targeting compound, is a promising candidate for future studies using mouse breast cancer models.
    VGD071
  • HY-P3057
    [D-Trp11]-Neurotensin
    		Modulator
    [D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension.
    [D-Trp11]-Neurotensin
  • HY-RS09640
    Ntsr1 Rat Pre-designed siRNA Set A
    		Inhibitor

    Ntsr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ntsr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ntsr1 Rat Pre-designed siRNA Set A
    Ntsr1 Rat Pre-designed siRNA Set A
  • HY-P1257
    Xenin-8
    Xenin-8, a C-terminal octapeptide, is a biologically active fragment of Xenin. Xenin is a 25-amino acid peptide of the neurotensin/xenopsin family. Xenin-8 stimulates basal insulin secretion and potentiates the insulin response to glucose in a dose-dependent manner (EC50=0.16 nM).
    Xenin-8
  • HY-159868
    SORT1-IN-1
    		Inhibitor
    SORT1-IN-1 (compound 2) is a SORT1 inhibitor.
    SORT1-IN-1
  • HY-14551B
    (S)-Osanetant
    		Antagonist 99.25%
    (S)-Osanetant is the S-enantiomer of Osanetant. Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia.
    (S)-Osanetant
Cat. No. Product Name / Synonyms Application Reactivity
Neurotensin Receptor Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.